My pulmonologist changed me to Anoro recently - had taken 24 doses when I began having severe discomfort in my upper left shoulder. It's not a sharp pain, but more a tingling and an awful soreness. It gets worse by evening. It is somewhat better after a night of sleep. Sometimes it seems to be a nerve, at other times more a muscle problem. In any case, it is severe enough that I've stopped the Anoro. I wonder if anyone else is having this kind of problem. I'm really disappointed because Anoro was a significant improvement for me.